How the New Maternal RSV Vaccine Helps Protect Newborns During Their Most Vulnerable Months

Respiratory Syncytial Virus (RSV) is one of the leading causes of hospitalization in infants under 6 months old. For decades, parents and healthcare providers have searched for better ways to protect newborns during RSV season.
Now, for the first time ever, there is an FDA-approved RSV vaccine available during pregnancy, a major advancement in maternal and newborn health.
In 2023, the FDA approved Pfizer’s Abrysvo for use during pregnancy to help protect babies from birth through their first 6 months of life. This breakthrough has quickly become one of the most important updates in maternal vaccination over the past five years.
π Why RSV Protection Matters
RSV is extremely common, but it can be especially dangerous for young infants. Each year in the U.S.:
- RSV causes 58,000–80,000 hospitalizations in children under age 5
- Newborns and infants under 6 months are at the highest risk
- Severe RSV can lead to pneumonia, bronchiolitis, and breathing difficulty
Because infants’ immune systems are still developing, they need protection during their earliest months, long before they can receive most vaccines themselves.
π‘οΈ How the Maternal RSV Vaccine Works
The RSV vaccine is given to pregnant individuals between 32 and 36 weeks of pregnancy.
During this time, the body makes RSV-fighting antibodies that pass naturally through the placenta to the baby. This gives newborns early immunity during their first months of life, when RSV is most dangerous.
Benefits include:
- Reduced risk of severe RSV infection
- Fewer infant hospitalizations
- Extra protection during peak RSV season (fall and winter)
- Safe, evidence-based immunity passed directly from parent to baby
This method of protection is similar to the maternal Tdap and flu vaccines, which have been safely used for many years.
π₯ What Health Organizations Are Recommending
In late 2023 and throughout 2024, leading health organizations updated their recommendations:
- CDC recommends offering the RSV vaccine during weeks 32–36 of pregnancy during RSV season.
- ACIP (Advisory Committee on Immunization Practices) supports maternal vaccination to reduce severe RSV outcomes in newborns.
- ACOG states that either the maternal RSV vaccine or the infant monoclonal antibody (nirsevimab) provides protection—families may choose the option best suited for them.
This flexibility means families can make an informed choice with their healthcare provider.
πΆ RSV Vaccine vs. Nirsevimab (Beyfortus): What’s the Difference?
Two RSV protection options now exist:
1. Maternal RSV Vaccine (Abrysvo)
- Given during pregnancy
- Protects baby through passive antibodies
- Lasts for first 6 months of life
2. Nirsevimab (Beyfortus)
- An injection for newborns shortly after birth
- Works like a long-lasting antibody
- Also protects infants for their first season
Most babies only need one of these options, not both.
π Why This Matters for Families
The availability of an RSV vaccine during pregnancy is a major step forward in newborn safety.
Parents now have another tool to reduce severe illness during one of the most vulnerable stages of life.
More families are choosing this option because it offers:
- Peace of mind
- Early immune protection
- Fewer hospital visits
- Strong safety data
- Clear guidance from trusted organizations
As RSV seasons become more intense in many parts of the U.S., this protection is becoming increasingly valuable.
π The Future of RSV Prevention
As research continues, maternal RSV vaccination is expected to become a routine part of prenatal care during RSV season. Hospitals, obstetric practices, and pediatric providers are working together to educate families and help them make informed decisions.
The goal is simple: protect newborns when they need it most.
Luxe Maternity Concierge is committed to helping expecting families understand new pregnancy care options and stay informed with the latest evidence-based guidance.
References
- Centers for Disease Control and Prevention (CDC). (2023–2024). Maternal RSV Vaccine Recommendations and Clinical Guidance.
- U.S. Food & Drug Administration (FDA). (2023). Approval of Pfizer Abrysvo for Use in Pregnancy.
- American College of Obstetricians and Gynecologists (ACOG). (2023–2024). RSV Vaccination in Pregnancy: Updated Practice Guidelines.
- Munoz, F. et al. (2023). Safety and efficacy of maternal RSV vaccination. New England Journal of Medicine.
- ACIP. (2023). Recommendations for RSV Prevention in Infants and Pregnant People.





